Dotmatics ELN: The Electronic Lab Notebook Built for Real Science
Capture every experiment, search any result, and stay audit-ready from day one. Built for scientists who refuse to choose between flexibility and rigor.
2M+scientists worldwide
125countries
ISO9001 & 27001 certified
See Dotmatics ELN in Action
Talk to a scientist on our team. No pressure, no script, just a real look at the platform.
Trusted by the world's leading scientific organizations
50%+
Reduction in experiment documentation time
Scientists report spending less time on manual data entry and more time on actual research after switching from paper or legacy ELNs.
3x
Faster experiment search vs. paper notebooks
Full-text, structure, and metadata search across every experiment, notebook, and result, not just the ones you remember to tag.
100%
Audit-ready from day one
Electronic signatures, immutable audit trails, and Part 11-ready controls are built in, so compliance doesn't slow your science down.
Why Dotmatics ELN
Everything your lab needs, nothing it doesn't
One platform that adapts to your workflows, not the other way around. Works for synthetic chemistry, molecular biology, formulation, screening, and every discipline in between.
Flexible Canvas, Not a Form
Capture any experiment type in a configurable canvas. Tables, chemical structures, images, sketches, spectra — exactly how your scientists want to work, not how IT configured a template three years ago.
Templates That Actually Scale
Standardize repeatable methods with protocol templates and structured fields. Build once, deploy across every team, and version-control everything so nothing gets lost when someone leaves.
Native Scientific Data Types
Molecules, reactions, sequences, images, spectra, and dose-response curves are first-class citizens. No workarounds, no attaching PDFs — data stays FAIR, searchable, and reusable.
Search Anything, Find It Fast
Full-text and structure search across every experiment, sample, result, and notebook. Permalinks let you share exact results with teammates in seconds instead of hunting through folders.
Integrated with Your Stack
Connect directly to registration, Prism, Luma Lab Connect, inventory, and third-party instruments. Open APIs let you route data to your data warehouse or BI layer without custom dev work.
Collaboration Without Friction
Real-time sharing across internal teams, sites, and external CRO partners. Granular permissions keep your IP protected while giving collaborators exactly the access they need and nothing more.
Inventory and Registration Built In
Track samples, compounds, plasmids, and reagents alongside your experiments. Full traceability from raw material to formulated product, with lineage you can actually audit.
Multi-Experiment Workflows
New in 7.5: build hierarchical experiment networks where precursors feed downstream experiments. Visualize your entire process capture workflow in one place, across any protocol type.
Security That Meets Regulated Environments
AES-256 encryption, TLS 1.2 in transit, role-based access, full audit trails, and electronic signature support. ISO 9001 and 27001 certified. Part 11-ready and GAMP 5 aligned.
Luma Lab Connect weaves structured AI throughout your ELN. Ask Luma Agent natural language questions across multi-table datasets, generate first-pass experimental write-ups automatically, and build data applications from screening files in days instead of weeks. Because Luma data is structured from the start, the AI doesn't guess — it reasons from your actual scientific record.
Built for Your Science
Electronic lab notebook software for every discipline
Whether you're capturing chemistry reactions, biologics workflows, or materials data, Dotmatics ELN has native data types and configurable templates built for the way your science actually works.
Chemistry ELN
Native reaction editor, chemical structure search, and stoichiometry tools built in. Supports synthetic chemistry, analytical chemistry, and medicinal chemistry workflows without workarounds or external plugins.
Biology & Biologics ELN
Capture molecular biology experiments, biologics discovery workflows, and cell-based assay data alongside native sequence and structure data types. Integrates with BioRegister for full sample traceability.
Small Molecule & Drug Discovery ELN
Connect compound registration, screening, PK data, and formulation in one structured environment. Supports the full small molecule discovery cycle from lead identification through candidate nomination.
Chemicals & Materials ELN
Purpose-built for formulation science, process chemistry, and materials characterization. Capture spectra, physical properties, and batch data in a structured online lab notebook trusted by organizations including BASF, Arkema, and Croda.
Multi-Disciplinary & Enterprise ELN
One ELN platform across chemistry, biology, and beyond. Different teams, different data types, same structured record — so data flows between disciplines instead of getting trapped in disconnected notebooks.
"Dotmatics ELN is built for multi-disciplinary science" — the same platform handles chemistry, biology, screening, formulation, and regulated manufacturing without separate tools for each team.
The experiment is in the ELN. But the results are stuck in attachments, and nobody can compare across runs. Dotmatics solves the documentation-to-visibility problem by turning structured ELN data into searchable, comparable, AI-ready insights.
Single-click cell editing in Canvas tables, Excel-like keyboard navigation
Preserved column settings per experiment, per user
Consistent chemical structure rendering across all workflows
Multi-experiment hierarchy with genealogy tracking
Luma Agent generates experimental write-ups, answers natural language queries against your data, and identifies synthesis facts your ELN didn't explicitly record
Closed-loop screening workflows: an ELN request triggers screening, instrument results are parsed and returned automatically, so scientists spend time interpreting, not formatting
Luma Agent works directly on your ELN data — experiment write-ups, tabular materials, instrument results, and attached documents — all in one context. Every output is traceable: you can see exactly which data the agent used to reach its conclusions, so scientists stay in control of the reasoning, not just the result.
Natural language queries
Ask Luma Agent to review an experiment as a whole — key results, attached documents, and any mismatches between the data. It pre-runs queries as new data lands, so end users get AI-driven insight without writing a single prompt themselves.
AI-generated write-ups
Luma Agent uses the Dotmatics ELN chemistry toolkit natively — rendering structures, running substructure searches, and calculating physicochemical properties as part of its reasoning. Chemistry isn’t translated into text first; it’s understood as chemistry.
App-building from screening files
Load assay results from a collaborator or instrument, describe what you need, and Luma Agent inspects the files, builds the table structure, and writes the data flow. Configuration work that typically takes weeks, done in a single prompt — with the agent’s plan visible and approvable before it executes.
Traditionally, unstructured experiment data is inaccessible to data science. Luma Agent changes that — operating on structured ELN records, not approximating from documents — so the insights are traceable back to the data that produced them.
Security & Compliance
Built for regulated science, not just lab notes
Dotmatics ELN meets the security and compliance bar for pharma, biotech, and regulated research organizations from day one.
ISO 9001:2015 and ISO 27001:2022 certified
FDA 21 CFR Part 11 compliant electronic records and signatures
GAMP 5 aligned, supporting GxP environments with dedicated expert support
GDPR compliant with data residency options
AES-256 encryption at rest, TLS 1.2 in transit
Immutable audit trails and comprehensive access controls
ISO 9001:2015Quality Management System
ISO 27001:2022Information Security Management
GAMP 5 AlignedQuality & security by design
21 CFR Part 11Electronic records & signatures
See It in Action
A real look at the Dotmatics ELN
Watch how research teams move from experiment design to analyzable data, without stitching together a dozen different tools.
Not all electronic lab notebook software is built the same. Here's what consistently separates Dotmatics from the alternatives.
AI that operates on structured scientific data, not generic text
Luma Agent works directly on your actual structured scientific record. It doesn't approximate from unstructured documents — it queries, summarizes, and generates write-ups from data that is structured from the start. Traceable, explainable, and verifiable by design.
Native multi-disciplinary data types — not file attachments
Molecules, reactions, sequences, spectra, and dose-response curves are first-class data objects, not PDFs attached to a text field. That means every scientific result is searchable, comparable, and reusable — not buried in a file.
Integrated inventory and registration — not a bolt-on
Sample management, compound registration, and reagent tracking are native to the same platform — not integrations to maintain. That means full traceability from raw material to result without leaving the ELN.
GxP-ready and 21 CFR Part 11 compliant out of the box
Electronic signatures, immutable audit trails, and GAMP 5-aligned controls are built into the platform from day one — not configured later. ISO 9001:2015 and ISO 27001:2022 certified with GDPR compliance included.
Proven at enterprise scale — 2M+ scientists, 125 countries
Dotmatics ELN runs across global pharma, biotech, chemicals, and materials organizations. The platform is built for multi-site, multi-team deployments with the security controls, permissions model, and performance that enterprise R&D requires.
Customer Stories
What scientists say about Dotmatics ELN
From early-stage biotech to global pharma, research teams trust Dotmatics to run their science.
"With the previous process it easily took an hour to analyze a single simple experiment. Now it takes less than ten minutes. Previously we analyzed all the data in Excel files, which was extremely hands on, took a long time, and had a lot of risk of error. Now there's an efficiency in terms of time but, more importantly for us, an improvement in quality, reproducibility, and consistency."
"Our power users built the system together with the Dotmatics experts, which made it their solution. This contributed to the fact that they were very open to the new system and had a positive attitude towards it. One of the biggest unexpected consequences we've seen is that it saves scientists hours of time spent analyzing data."
"Dotmatics has transformed our R&D processes by providing an integrated, cloud-based platform that meets the diverse needs of our multidisciplinary teams. The transition has significantly improved our data management, streamlined our workflows, and enhanced internal communication. We've seen a notable increase in user engagement, reflecting the platform's positive impact on our research and decision-making capabilities."
FAQ
Common questions
Things R&D leaders and IT teams typically ask before a demo.
Dotmatics ELN is built for multi-disciplinary science. It supports synthetic and analytical chemistry, molecular biology, screening, formulation and process capture, biologics workflows, materials science, and custom experiment types. The same platform handles early discovery notebooks and regulated manufacturing workflows, so your teams don't need separate tools as science matures.
Dotmatics ELN connects natively to compound registration, BioRegister, inventory, screening, data discovery, and Prism within the Dotmatics platform. For third-party systems, the open REST API lets you route data to your data warehouse, LIMS, or BI layer. The 7.5 release also includes direct instrument file linking via Luma Lab Connect, reducing manual data entry across your stack.
Our implementation team works directly with your scientists and IT to build protocol templates that match your existing workflows, not generic ones that need to be retrofit. Most organizations are capturing experiments in the system within the first few weeks. We involve end users early, which is why adoption rates are high. Dotmatics employees are also industry scientists, so they can support your GxP integrations and specific scientific needs directly.
Dotmatics ELN supports real-time data sharing across internal teams, geographic sites, and external CRO partners, all from one instance. Granular, role-based access controls let you give collaborators exactly the access they need while keeping your IP protected. Permalinks make sharing a specific experiment result or notebook as simple as copying a link.
Yes. Dotmatics ELN is built in alignment with GAMP 5 guidelines and supports integration into GLP and GMP environments. The platform includes FDA 21 CFR Part 11 compliant electronic records and signatures, comprehensive audit trails, ISO 9001:2015 and ISO 27001:2022 certifications, and GDPR compliance. Our team includes industry experts who can support your GxP validation and compliance requirements directly.
Version 7.5 brings several meaningful ELN improvements: multi-experiment workflow support is no longer restricted to formulation protocol types, Canvas tables now have Excel-like keyboard navigation and persistent column settings, per-experiment properties can be added across multiple protocols at once, and chemical structure rendering is now consistent across reaction workflows and the ELN. Data discovery also gained conditional formatting in pivot views and cleaner Excel exports. If you're currently on an older version or evaluating competitors, 7.5 closes several gaps.
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ISO 9001:2015
ISO 27001:2022
GAMP 5 Aligned
21 CFR Part 11
